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German health authority rejects added value of amyloid drugs in Alzheimer’s treatment

The German health authority has rejected added value claims for several Alzheimer's medications

New research from Magdeburg suggests that memory loss in Alzheimer’s disease may not be permanent, challenging the long-held assumption that cognitive decline stems solely from irreversible brain cell death. A review of 17 studies involving over 20,000 participants found that widely used anti-amyloid drugs like Lecanemab reduce brain plaque but deliver minimal clinical benefit after … Weiterlesen …

Germany’s G-BA blocks added-benefit status for Alzheimer’s drug Lecanemab

Cognitive gains failed to materialize after 18 months

New clinical data has severely undercut the promise of antibody-based Alzheimer’s therapies, showing that these drugs offer minimal improvement in cognitive function while increasing the risk of brain swelling. The findings emerge as a critical blow to a treatment path that the European Commission first approved in 2025, specifically targeting the underlying disease processes in … Weiterlesen …